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However, evidence from lipidomic mass spectroscopy indicates that the mole fractions of PPIs are nearly 10 times more enriched in the nucleus 1 , 2 , while the phospholipid profiles are conserved in plant and animal nuclei 3 , 4. How PIP 2 regulates nuclear function and in what form PPIs exist in the nucleus has been an open question for decades 7 , 8. Together, these early observations imply that nuclear phosphoinositides have a role in responding to DNA damage.

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